The Surrey & North West Sussex Area Prescribing Committee recommends the off label use of domperidone for the treatment of nausea and vomiting in pregnancy only when prescribed within a secondary care setting. Treatment duration is restricted to a maximum of one week in all patients*.

Prescribers should ensure that the patient understands the risks and consents to using domperidone off-label noting the MHRA drug safety alert (December 2019)  (link below).

Primary care prescribers should ensure that patient medication records include any medicine for which prescribing remains the responsibility of secondary or tertiary care. This will ensure that GP records, which are accessed by other healthcare providers, are a true and accurate reflection of the patient's medication

Domperidone will be considered RED on the traffic light system for this indication.

*MHRA drug safety update (December 2019- Domperidone for nausea and vomiting: lack of efficacy in children; reminder of contraindications in adults and adolescents : https://www.gov.uk/drug-safety-update/domperidone-for-nausea-and-vomiting-lack-of-efficacy-in-children-reminder-of-contraindications-in-adults-and-adolescents