The Surrey & North West Sussex Area Prescribing Committee recommends the use of domperidone for the treatment of nausea and vomiting as follows:

• GREEN - For relief of the symptoms of nausea and vomiting only in adults and adolescents 12 years of age or older and weighing 35kg or more. Domperidone should be used at the lowest effective dose for the shortest possible duration and maximum treatment duration should not usually exceed 1 week

• RED - For any indications in children younger than 12 years or those weighing less than 35kg, only when prescribed within a secondary care setting and treatment duration should not exceed one week.

These changes are in line with the MHRA advice published in December 2019. Domperidone is no longer licensed for use in patients under 12 or those patients weighing less than 35kg. 

Prescribers should ensure that the patient/carer/legal guardian understands the risks and consents to using domperidone off-label noting the MHRA alert (updated 2019)

 MHRA Drug Safety Update, December 2019: https://www.gov.uk/drug-safety-update/domperidone-for-nausea-and-vomiting-lack-of-efficacy-in-children-reminder-of-contraindications-in-adults-and-adolescents

Primary care prescribers should ensure that patient medication records include any medicine for which prescribing remains the responsibility of secondary or tertiary care. This will ensure that GP records, which are accessed by other healthcare providers, are a true and accurate reflection of the patient's medication