PAD - Prescribing Advisory Database
PLEASE NOTE : This is a development system.

For Surrey PAD, please go to https://surreyccg.res-systems.net/PAD.

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PAD Profile : Insulin glargine - Diabetes Mellitus

Keywords :
Biosimilars, long acting insulin analogues, lipohypertrophy, cutaneous amyloidosis
Brand Names Include :
Abasaglar, Lantus, Semglee

Traffic Light Status

Status 1 of 1.

Status :
Green
Formulations :
  • Injection
Trust Alignment :
Primary Care
ASPH
RSFT
SASH
SABP
Links :
Comments :
No comments returned.
Documents :

Guidelines

The following guidelines are available for this indication.

Other Drugs

Other Indications

No indications returned.

Additional Documents

Committee Recommendations

Date
Committee Name
Narrative
07 February 2024
Surrey Heartlands Integrated Care System Area Prescribing Committee (APC)

The Surrey Heartlands Integrated Care System Area Prescribing Committee (APC) recommends biosimilar insulin as a treatment option for patients with diabetes mellitus where it is indicated, in line with NICE Guidelines NG17NG28 & NG18

Biosimilar insulin will be considered for use for the same APC agreed indications and traffic light status as its reference product (RP).

The Medicines Healthcare Products Regulatory Agency (MHRA) states that biosimilar medicines are interchangeable with the original biological product and with other biosimilars when approved, which is reflected in government guidance on the licensing of biosimilar products and supported by the joint EMA-HMA statement on interchangeability. Once authorised, a biosimilar product is considered to be interchangeable with their RP, which means a prescriber can choose the biosimilar medicine over the RP (or vice versa) and expect to achieve the same therapeutic effect. Likewise, a biosimilar product is considered to be interchangeable with another biosimilar to the same RP.

The MHRA recommends prescribing biosimilar insulins by brand name and that the device is specified. This information should be included in patient documentation (eg, insulin safety card/patient insulin passport) to ensure that substitution of a biosimilar product does not occur when the medicine is prescribed or dispensed.

NHS England recommend that where a biosimilar is available, prescribers and patients are encouraged to have a shared decision-making conversation as part of their medicines review to consider using the biosimilar. This applies to both new patients and those who are already receiving the reference product.

The insulin pen delivery device may be unique to the insulin brand, if so patients will need to be instructed on the correct u

14 July 2021
Surrey Heartlands Medicines Safety Committee (MSC)

MHRA Safety Alert

Cutaneous amyloidosis can be considered as a differential diagnosis to lipodystrophy when a patient presents with subcutaneous lumps at an insulin injection site.  Healthcare professionals are advised to ensure that all people who inject insulin are taught to check for signs of developing cutaneous amyloidosis or lipohypertrophy and that they should report any abnormalities to their healthcare professional.

Refer to the Cutaneous amyloidosis Guidance for Healthcare Professionals below

04 May 2016
Surrey & North West Sussex Area Prescribing Committee (formerly Prescribing Clinical Network)
The PCN recommends Abasaglar (Insulin glargine Biosimilar) as a treatment option for patients with Type I diabetes mellitus where an insulin glargine is indicated, in line with NICE Guideline 17 (NG17) Type 1 diabetes in adults: diagnosis and management. Please note: The Medicines Healthcare Products Regulatory Agency (MHRA) recommends that all biosimilar medicines are prescribed by brand. https://www.gov.uk/drug-safety-update/biosimilar-products
05 April 2016
Surrey & North West Sussex Area Prescribing Committee (formerly Prescribing Clinical Network)

The PCN recommends Abasaglar (Insulin glargine Biosimilar) as a treatment option for patients with Type II diabetes mellitus where an insulin glargine is indicated, in line with NICE Guideline 28 (NG28) Type 2 diabetes in adults: management

Please note: The Medicines Healthcare Products Regulatory Agency (MHRA) recommends that all biosimilar medicines are prescribed by brand. https://www.gov.uk/drug-safety-update/biosimilar-products

06 October 2011
Surrey & North West Sussex Area Prescribing Committee (formerly Prescribing Clinical Network)

The committee noted the high use of insulin analogues across Surrey (this is a national QIPP initiative but Surrey are particularly high prescribers). It was agreed that NPH insulins would be used first line but there were indications when analogues would be appropriate - see policy statement

Associated BNF Codes

06. Endocrine System
06.01.01. Insulin
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